Check with your doctor before traveling, but your usual, routine vaccinations should be up to date, including MMR, tetanus, and polio. Hepatitis A, typhoid and rabies vaccinations are also recommended, although if you’re on a self-drive safari and spending a lot of time in the wilderness and away from built-up areas, the risk of infection is very low.
Malaria is not found in Gaborone, the Central Kalahari or the Kgalagadi, but infection rates increase as you head further north. The highest risk is during summer and in or near human-populated areas. Apply insect repellent and wear long, loose-fitting clothing at night, and consult your doctor about prophylaxis medication before you travel.
There’s no risk of yellow fever in Botswana, but if you’re arriving from a yellow fever region you will be asked to show proof of vaccination. Yellow fever areas include most of Central Africa, and parts of Central and South America.